Testolone is an unapproved drug that comes with a slew of warnings. Why do people use it? Learn about the risks and dangers of RAD-140.
Disclaimer: While Testolone isn’t illegal to have, it is illegal to sell and prohibited in amateur and professional league sport. Some of our subscribers who were already taking the drug requested we commission a post on it, and we are simply providing information that is offered in the clinical and scientific literature.
Testolone is a dangerous experimental drug not approved for human consumption. Don’t take it under any situation.
What is RAD-140 (Testolone)?
RAD-140, also referred to as Testolone, is an investigational new medication that has become popular among bodybuilders, who claim that it’s muscle-building effects. RAD-140 belongs to a class of compounds called selective androgen receptor modulators, or SARMs.
SARMs bind to androgen receptors which are located in various regions of the body. Usually, these receptors interact with androgens, which are a group of steroid hormones. Androgens such as testosterone, dihydrotestosterone, and androstenedione are naturally created by the body.
SARMs and testosterone often have similar consequences because they operate on the exact same receptor. The planned targets of SARMs include the muscles, bones, and liver.
SARMs are of particular interest to investigators because they are selective about where they operate. They mostly aim for muscle and bone cells and seem to have minimal impacts on the prostate and other organs. Because of this, some investigators think that SARMs could potentially treat hormone-related or muscle-wasting ailments with fewer side effects than existing therapies, but this is an unproven hypothesis with data to back this up.
This potential has also made SARMs a popular choice over testosterone or steroids for bodybuilders. Although steroids and testosterone boost muscle growth, they also have undesirable effects on the prostate and reproductive organs, among others.
RAD-140 (Testolone) is a SARM: it imitates testosterone but mainly targets the muscles, which some belief could potentially lessen its side effects in comparison with testosterone or other steroids. No info to back up this hypothesis.
- May increase muscle mass
- Might Increase fat-burning
- Might protect brain cells
- May be beneficial for certain breast cancers
- May suppress testosterone
- May cause hair loss, tiredness, and mood swings
- No human studies
- Long-term dangers are unknown
- Security profile and total side effects are unfamiliar
- The appropriate dosage is unknown
Use in Bodybuilding
RAD-140 has become popular in men who have low testosterone levels who wish to avoid testosterone replacement therapy but are looking to maintain their physical and sexual performance. Such usage is still totally anecdotal, without research to back it up.
In fact, without complete studies, testosterone replacement therapy remains a more powerful approach than utilizing SARMs such as Testolone. Bear in mind that we understand nothing about the safety profile of the experimental, unapproved medication, while testosterone’s effects are well-studied and predictable.
Research is presently exploring the possible role of RAD-140 in increasing muscle mass, combating breast cancer, and protecting brain cells.
Regardless of the dearth of safety research in people, bodybuilders use RAD-140 to improve strength and endurance. RAD-140 is not illegal, but it’s banned in specialist sports. Together with all other SARMs, RAD-140 is on the banned list of the World Anti-Doping Agency.
Some athletes think RAD-140 can boost testosterone, muscle mass, and physiological performance. It’s prohibited in professional sports, and with no more clinical trials, we don’t know if it works or how safe it may be.
Mechanism of Action
RAD-140 functions by stimulating androgen receptors within the body. It targets receptors in the bone and muscle and has had little to no observed effect on the reproductive organs.
This compound stimulates muscle development by boosting the evolution of muscle tissues and cells.
The discerning ability of SARMs is not completely understood yet. According to some investigators, they may target and selectively activate different proteins than testosterone. This results in only particular androgen receptors — mainly from the muscles being triggered.
The chemical structure of RAD-140 is very different from the arrangement of steroid hormones like testosterone. Therefore, the pathways that convert testosterone to other hormones (like estrogen) cannot behave on Testolone.
Based on a study in rats, some researchers have indicated that RAD-140 could activate receptors in wounded regions of the brain. In the minds of rats given RAD-140, MAPK activity improved, thus protecting neurons from damage.
RAD-140 activates androgen receptors in muscles, but not in most other tissues. Some researchers feel this reduces Testolone’s potential to generate side effects (compared to testosterone or other steroids), but more research is needed.
RAD-140 (Testolone) vs. Ostarine
Ostarine, also known as Enobosarm, is a favorite SARM that has undergone limited testing in humans. 1 clinical trial has investigated Ostarine’s ability to prevent drastic weight loss (cachexia) brought on by severe ailments.
RAD-140 and Ostarine are equally SARMs; some researchers have discovered minimal effects on the prostate and reproductive organs, but without high-quality clinical trials, we can not know if this is really the case.
The claims under are strictly anecdotal and have not been investigated in any relevant research.
Anecdotally, Testolone and Ostarine disagree when it comes to their effects on fat and muscle. According to anecdotal reports from people using SARMs, Ostarine has milder muscle-building results and is best for fat reduction. It’s the typical selection for”cutting cycles” and for those that want to gain modest but lean muscle mass. On the other hand, several of these very same anecdotes report that RAD-140 is a stronger SARM that provides better muscle growth. It is a more popular choice for bulking.
Remember that none of these anecdotes have ever been examined in clinical research, and they should be obtained with several large grains of salt. Individuals’ reports of their own experience could be interesting, but they cannot substitute high-quality, placebo-controlled studies conducted by experts in the field.
Possible Uses of RAD140
1) Increasing Muscle Mass
RAD-140 is popular in the bodybuilding community for its supposed muscle-building effects. Some researchers feel that, much like other SARMs, it may increase muscle development without the unwanted effects of conventional steroids.
In spite of this popularity, the scientific proof behind RAD-140 is scant.
At this time, there’s only 1 animal study that analyzed RAD-140’s effect on muscle growth. In the study, researchers tested different doses in 9 monkeys. They discovered that monkeys that obtained RAD-140 daily had improved lean muscle mass after 28 times.
Human studies of RAD-140 still haven’t been performed.
RAD-140 is popular in bodybuilding, but no clinical trials have examined its safety and efficacy in humans.
2) Breast Cancer
Researchers are currently exploring RAD-140 for possible action against breast cancer.
A common kind of breast cancer known as androgen and estrogen receptor-positive (AR/ER+) is sensitive to hormones. Medicines that affect such receptors, like SARMs, might have cancer-fighting potential.
In a mobile study, RAD-140 ceased the growth of AR/ER+ breast cancer by blocking the effects of estrogen.
Specifically, RAD-140 appears to suppress the ESR1 gene. This gene is responsible for creating estrogen receptors. Without adequate receptors, estrogen becomes inactive.
3) Brain Outcomes
Androgens play an important role in protecting the mind. They could increase brain cell growth, enhance memory, and decrease amyloid-beta accumulation. Amyloid-beta plaques are among the main causes of Alzheimer’s disease.
In a rat study, RAD-140 protected brain nerves from harm from amyloid-beta plaques. Furthermore, RAD-140 and testosterone proved equally good at shielding against neurotoxins.
Some RAD-140 users report better sleep, but there aren’t any studies to back up this effect. The same is true for its supposed ability to improve sexual performance — although this might be related to its testosterone-mimicking consequences.
Users assert RAD-140 enhances sleep and sexual functionality, but no research to back this up.
4) Weight reduction
Some people believe that SARMs boost muscle mass and decrease body fat.
Only one study in monkeys looked at RAD-140’s effects on muscle and fat. Although it increased lean muscle, the impact on body fat was unclear.
The analysis did find that RAD-140 enhances cholesterol levels. Furthermore, a greater muscle mass can increase energy usage to further promote fat reduction, however, these factors did not play out to lower body fat from the single, accessible study. Thus, there is currently no evidence that Testolone promotes weight loss.
Some people believe SARMs to increase muscle mass and decrease body fat, but the limited research available does not support this usage.
Limitations and Caveats
RAD-140 benefits have yet to be explored in human studies. This drug has only been examined in monkeys and rats. Although it’s used as a supplement by athletes, the long term advantages and hazards of human use are unknown. Testolone is an unapproved medication with very limited evidence of efficacy or safety: that’s, we don’t know how safe it’s, or perhaps if it functions.
RAD-140, just the same as all other SARMs, is prohibited in professional sports from the World Anti-Doping Agency. Researchers have developed approaches to discover RAD-140 in drug evaluations.
SARM users should be careful when buying products online.
In a recent study, investigators examined 44 different SARM products which were sold online. They found that only 52% actually comprised SARMs.
Additionally, 39 percent of goods contained an unapproved medication and 25% contained materials not listed on the label.
Individual studies haven’t confirmed the efficacy and safety of RAD-140. It is prohibited in professional sports and many products available on the internet are dangerous. Because of this, we strongly recommend against taking this drug.
RAD-140 Side Effects and Dangers
RAD-140 is a new investigational substance. Its safety and side effects haven’t been clinically assessed yet.
According to how SARMs operate, its proponents state that RAD-140 should trigger fewer undesirable effects than testosterone, but that really is completely unproven. RAD-140 still has the potential to cause testosterone-related side effects. These may include:
- Breast tenderness/growth in guys
- Abnormal body hair growth in women
- Changes in sex drive
- Male pattern baldness/hair loss
- Mood swings and stress /melancholy
- Nausea and vomiting
Bodybuilders commonly report hair loss as a side effect, which can be reversed once they cease taking RAD-140.
Clinical trials haven’t tested the safety of RAD-140 yet. Despite online claims, it may still cause baldness and breast development in men, changes in sexual drive, and mood disorders.
Testosterone Suppression & Estrogen Effects
SARMs can suppress the body’s natural testosterone production. It may slightly raise blood estradiol, very similar to other SARMs. Some people today claim that RAD-140 is unique since it will not aromatize to estrogen or shut down your testosterone, but no studies to back up these claims. Plus, user reviews suggest otherwise.
In theory and in practice, RAD-140 can potentially bring about testosterone suppression and estrogen buildup. This can cause decreased libido, depression, and fatigue. Users advocate PCT (Clomid or Nolvadex) to restore hormone levels — that goes to say it is probably not as selective as some advocates assert.
The amount of suppression or estrogen-like effects may vary — many users report being more sensitive to it, while it doesn’t impact others as much. Greater doses and longer use of any substances will always raise your risk of unwanted side effects, also RAD-140 is no exception.
There’s now no way of knowing all of the potential side effects of Testolone due to the dearth of clinical studies. This is only one of many reasons we strongly recommend against taking RAD-140.
RAD-140 can suppress testosterone and boost estrogen, leading to decreased libido, depression, and exhaustion. Long-term use of higher doses increases your chance of unwanted effects.
Among the biggest drawbacks of using testosterone would be the unwanted effects it has on prostate cancer. Testosterone enlarges the prostate and possibly raise the risk of prostate cancer.
The selective character of SARMs means they should have little to no influence on the prostate. Based on present research, RAD-140 does not seem to grow the size of the prostate cancer. However, research has not yet been performed in humans, however, and lots of users have reported encounters that contradict the supposed selective benefits of Testolone. Complete scale clinical trials might well find adverse impacts on the prostate.
RAD-140 Dosage & Supplements
There is absolutely not any set dose for RAD-140, as it hasn’t been researched in people . Until and unless clinical trials sufficiently research this medication, in circumstance and for a particular function, a secure dosage doesn’t exist.
Bodybuilding resources generally suggest a dose of 10 to 30 mg every day for men and 5 to 10 milligrams per day for girls.
Users typically cycle RAD-140 for 8 to 12 weeks. The off-cycle can vary: some urge they continue as long as the cycles, while others believe that a briefer off-cycle of 6-8 months is sufficient.
Veterans will tailor these depending on their labs, checking to see how the cycles influenced their liver markers and hormone balance.
These dosages are only speculative and never backed up by scientific research.
RAD-140 appears to have great bioavailability. According to a study in monkeys, about 70% of the medication is absorbed into the body when ingested.
On account of the dearth of clinical trials, there is no established RAD-140 dosage. Bodybuilders normally cycle it over 8-12 weeks at 10-30 mg/day (5-10 /day for women). No scientific research backs up these doses.
To be able to boost results, bodybuilders will occasionally combine RAD-140 with different SARMs or steroids. Consumers have reported”piling” with Ostarine, ibutamoren, and conventional steroids such as Primobolan. The combination with Ostarine is reported to improve recovery. For cutting or endurance gains, it’s usually stacked with Cardarine.
We can’t stress this enough: these “stacks” are very dangerous. Each one of those drugs is unapproved and insufficiently studied. None of them have complete safety profiles. We strongly recommend against taking anyone among these substances, let alone two or three at once.
The usage of SARMs and steroids can suppress the body’s ability to produce testosterone. Most experienced users recommend post-cycle treatment (PCT) after each cycle of RAD-140.
PCT usually involves taking Nolvadex and Clomid to restore hormone levels. The perfect duration of PCT can vary depending on the duration of SARM use. Users typically report taking PCT for 3 to 4 weeks.
Users frequently stack RAD-140 with other SARMs or steroids. The majority of them recommend PCT with Nolvadex and Clomid for 3 to 4 months after each cycle. But without real clinical studies, there are no secure means of taking these substances.
Several online users believe that this chemical is a safer option for testosterone replacement therapy. They cite anecdotal reports and concepts which have no supporting data or studies of any kind to investigate them.
Based on anecdotal reports of negative effects, the absence of clinical trials, and the dearth of available data, we believe that testosterone replacement therapy — under the supervision of a licensed doctor — remains a much safer alternative to carrying this, or some other, SARM.
Patients with hormonal deficiencies or imbalances should approach the use of RAD-140 with care.
Mutations in the gene coding for the androgen receptor can alter the body’s reaction to RAD-140. Depending upon the mutation, RAD-140 can have increased or decreased activity in the body. Individuals with variations in this gene may also be susceptible to more side effects with RAD-140. But this has yet to be researched in more detail.
As an unapproved drug used as a nutritional supplement by bodybuilders, people say they believe that RAD-140 is great for increasing muscle mass while at the same time reducing body fat. Some believe it also enhances the speed endurance, and endurance through exercise.
Users also report that RAD-140 functions fast, with evident benefits in no more than 3 to 4 months.
RAD-140 tends to induce testosterone suppression and many users opt-in for PCT after.
Side effects reported by users include hair loss, tiredness, and diminished sex drive. Others have experienced mood fluctuations and joint pain. A couple of users who do lab tests after cycles had elevated liver markers (ALT and AST) after taking RAD-140.
We advise talking to a doctor before taking any medication, particularly an unscheduled drug with limited long-term security information in humans.
RAD-140 is an investigational medication popular for its muscle-building action. It is a SARM that might boost muscle mass. Research is presently researching RAD-140’s effects on health, as its safety, effectiveness, side effects, and long-term dangers in humans are unknown. Side effects generally reported by users include temporary hair loss, diminished sex drive, and mood fluctuations. Like all SARMs, RAD-140 is prohibited (and actively screened for) in professional sports. Users must also be careful when purchasing SARMs on the internet; many goods do not include the ingredients that are advertised. Depending on the available evidence, a lack of human studies demonstrating efficacy and safety, and anecdotal reports of adverse consequences, we don’t advise using Testolone. Physician-supervised testosterone replacement therapy is a much better approach than untested SARMs.